Pepperoni Pizza Casserole: A Delicious Twist on Your Favorite Pizza


Pepperoni Pizza Casserole is a delightful fusion of classic pizza flavors and the comforting warmth of a casserole. Ideal for busy weeknights or cozy family dinners, this dish offers a unique twist on everyone’s favorite pizza. With its tantalizing blend of ingredients and simple preparation, it’s sure to become a beloved staple in your meal rotation.


  • Uncooked spiral or penne pasta
  • Ground beef
  • Onion, chopped
  • Mushroom stems and pieces, drained
  • Tomato sauce and pizza sauce
  • Tomato paste
  • Sugar, garlic powder, onion powder, dried oregano
  • Shredded mozzarella cheese
  • Sliced pepperoni
  • Grated Parmesan cheese


  1. Preparation: Start by preheating the oven and cooking the pasta according to the package directions.
  2. Cooking the Meat: Brown the ground beef with chopped onion, then drain any excess fat.
  3. Combining Ingredients: Mix in mushrooms, sauces, and seasonings. Combine with the cooked pasta.
  4. Assembling the Casserole: Layer the pasta mixture with mozzarella cheese in a baking dish, topping it with pepperoni and Parmesan cheese.
  5. Baking: Cover and bake initially, then uncover and bake until heated through.

Preparation Time

  • Total Time: Approximately 1 hour
  • Prep Time: 15-20 minutes
  • Cook Time: 40-45 minutes


  • This recipe yields around 8 to 12 servings, perfect for a family meal.


  1. Can I substitute the pasta? Yes, you can use any short pasta variety.
  2. Is it gluten-free? Not as is, but you can use gluten-free pasta.
  3. Can I use different cheeses? Absolutely, feel free to experiment with various cheese types.
  4. What if I don’t have pizza sauce? Marinara or spaghetti sauce can be used as a substitute.
  5. How can I store and reheat the casserole? Store in the fridge for 3-4 days or freeze. Reheat in the oven or microwave.


Pepperoni Pizza Casserole is a fantastic blend of comfort and flavor, perfect for those who love the taste of pizza but want the heartiness of a casserole. Its versatility in ingredients and ease of preparation make it a great option for any home cook. Whether you’re looking for a new weeknight dinner idea or a dish to wow at a potluck, this casserole is sure to satisfy all pizza cravings in a more wholesome and family-friendly format. Remember, the best part about cooking is making it your own, so feel free to get creative with the toppings and ingredients!